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CDMO Education Centre

Conventional cancer treatments (e.g. surgery, chemotherapy/radiation) do not specifically target cancer cells and, as a result, can cause extensive off-target damage, and complications for patients.

In the last several years, ground-breaking research and advancements in genetic engineering have led to the development of a novel treatment strategy, known as immune therapy, that is rapidly emerging as an alternative to conventional cancer treatments. By re-deploying the body’s own... Read More

New cell and gene therapies are rapidly being translated into the clinic. The potential for these new therapies is driving the industry to develop safe and reproducible cell culture systems. Increasingly, this has meant including the development of a unique, chemically defined (CD) and animal component free (ACF) medium as a standard part of the cell and gene therapy development process.

A few basic definitions are important to help navigate a market where defined media are... Read More

In the field of cell and gene therapy, there are two main types of viral vectors: adeno associated virus (AAV) and Lentivirus (LV). The manufacture of these vectors is dependent on the regulatory requirements dictated by its end use. AAVs are most commonly used to deliver gene therapies – meaning they will be administered directly to a patient. In contrast, LV is typically used as an input material to genetically modify cells used for cell therapies (e.g. CAR-Ts) and is not included in the... Read More

A contract development and manufacturing organization (CDMO) is a company with specialized infrastructure and expertise that provides services on a contract basis to other companies who want to outsource product development and manufacturing. For cell & gene therapy (CGT) developers CDMO’s can provide a range of services including early stage product and process development to GMP manufacturing for clinical trials. The benefits of working with a CDMO are customized solutions, reduced... Read More